(A) Representative histopathologic features and (B) polymorphonuclear neutrophil (PMN) infiltration index of kidney tissue sections obtained from LPS-induced rhabdomyolysis rats.

Depicted are changes in PMN infiltration index at the end of experiment (at 6 h) in different groups of animals that received vehicle at time 0 (Control, n = 3), received vehicle at time 0 and then received procainamide at 1 h (Control + Pro, n = 3), received LPS at time 0 (LPS-induced rhabdomyolysis, n = 3), and received LPS at time 0 and then received procainamide at 1 h (LPS-induced rhabdomyolysis + Pro, n = 3). All data are obtained using the same rats in Fig 1 and expressed as mean ± SEM. *P < 0.05, all versus Control rats; ^#P < 0.05, with versus without procainamide in LPS-induced rhabdomyolysis rats. Arrows represent neutrophil infiltration. Original magnification x 400.