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(A) Immune responses against OSP linked to BSA via squarate (ratio ~5:1; OSPsq:BSA) versus an unrelated oligosaccharide linked to BSA via squarate (B; ratio ~6:1; sq:BSA-synthetic conjugate 3, see text) induced by vaccination with alum and OSP linked to rTTHc via squarate (ratio 5:1; OSP:rTTHc).

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posted on 2015-07-08, 02:54 authored by Md. Abu Sayeed, Meagan Kelly Bufano, Peng Xu, Grace Eckhoff, Richelle C. Charles, Mohammad Murshid Alam, Tania Sultana, Md. Rasheduzzaman Rashu, Amanda Berger, Geoffrey Gonzalez-Escobedo, Anjali Mandlik, Taufiqur Rahman Bhuiyan, Daniel T. Leung, Regina C. LaRocque, Jason B. Harris, Stephen B. Calderwood, Firdausi Qadri, W. F. Vann, Pavol Kováč, Edward T. Ryan

Day 0 and day 56 serum from mice vaccinated with OSP:rTTHc were analyzed using plates coated with squarate-BSA (synthetic conjugate 3; see text) or OSPsq:BSA (OSP:BSA).

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    PLOS Neglected Tropical Diseases

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    molar loading ratioMemory B Celllpscholera conjugate vaccineTetanus Toxin Heavy Chainospcholerae O 1 Inabacholerae O 1 Inaba strain PIC 018Mice BackgroundVibrio choleraeconjugate vaccineIntestinal lamina proprial IgA responsesmemory B cell responsesmouse survival cholera challenge model.ConclusionWe report developmentintradermal vaccinationimmunization.Principle FindingsImmunized micesquaric acid chemistryLamina Proprial Responses

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