AUROC and AUPR for all tested methods.

For each of the 15 networks of the DREAM5 SYSGEN A challenge, we evaluated the performance of the different methods using the AUROC and AUPR as metrics. To better compare AUROC and AUPR values, they were scaled to the maximum value obtained across methods for each network. Results were then summarized over all 15 networks. The bars show the mean AUROC (left-oriented bars) and AUPR (right-oriented bars) per method, error bars indicate one standard deviation. RF.sf+LASSO outperforms the DREAM best performer and all our tested approaches in terms of AUPR. Differences between the methods on AUROC values are less pronounced.