ABO locus and PLIP/ACE levels.

(a) Box plots for the P-LIP and ACE level per each genotype of the significant SNPs at the ABO locus in the combined population of Takahata and Yamagata with adjustment for age and gender as covariates. These plots show the difference and direction of effects of each SNP on P-LIP and ACE. (b) One-way ANCOVA for the means of the P-LIP and ACE levels per genomically-deduced ABO group in the combined population with adjustment for age and gender as well as rs4356 (the effect of ACE1), in which AA is set as the baseline group in the corner-point parameterization denoted as “base”. Asterisks denote that the significance level reached in the one-way ANCOVA (*** <0.001).