Xanthine oxidase pathway response.
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posted on 2023-09-08, 17:49 authored by Ryan E. Feaver, M. Scott Bowers, Banumathi K. Cole, Steve Hoang, Mark J. Lawson, Justin Taylor, Brian D. LaMoreaux, Lin Zhao, Brad R. Henke, Brian A. Johns, Andrew C. Nyborg, Brian R. Wamhoff, Robert A. FiglerA) Principle component analysis of DEGs show febuxostat (FBX, 100 μM, green) is different from vehicle (black) and oxypurinol (OXP, 500 μM, red). B, C) Heatmaps from PCA; PC1 and PC2 represent 2 different gene clusters. Gene expression (log2CPM Z-score; red = upregulation, blue = downregulation); columns represent treatment replicates; n = 4 in ECs (B) or SMCs (C). D, E) Select pathways regulated by XOi in ECs (D) or SMCs (E). ECs = endothelial cells, SMCs = smooth muscle cells. LogFC = log fold change, FDR = false discovery rate.
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