Wnt affects hindbrain ventricle size.

Quantification of brain ventricle size differences between DMSO controls and pharmacological manipulation of components of the Wnt pathway. XAV939 treated animals had significantly reduced ventricles (56% reduced, p-value 0.001) when compared to DMSO controls (M_XAV939 = 90.69 μm³, SD _XAV939 =  30.73, M_DMSO = 206.95 μm³, SD_DMSO = 23.05). Windorphen and ICG-001 treated animals had significantly reduced ventricles (70% reduced, p-value 0.01) when compared to DMSO controls (M_Wind+ICG = 87.47 μm³, SD _Wind+ICG =  71.48, M_DMSO = 148.48 μm³, SD_DMSO = 23.87). SB216763 treated animals had significantly reduced ventricles (40% reduced, p-value 0.001) when compared to DMSO controls (M_SB = 99.71 μm³, SD _SB =  34.93, M_DMSO = 140.21 μm³, SD_DMSO = 27.58).

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