Water intake while rats were group housed in standard cages.

<p>(A) Water intake in the Lewis rat groups. Water intake in the Lewis+HWI rats was significantly increased water intake at all timepoints during the study period compared to the NWI group. *p<0.001 and †p<0.05 versus age-matched NWI Lewis rat. (B) Water intake in the LPK rat groups. Water intake in the LPK+HWI group was increased only up to week 10, after which it was similar to LPK+NWI rats. *p<0.001 and †p<0.05 versus the age-matched NWI group. Please see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0209186#sec002" target="_blank">Methods</a> for details on calculation.</p>