Validation of TMZR-RGPI model for GBM.
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posted on 2025-02-04, 18:33 authored by Haofei Wang, Zhen Liu, Zesheng Peng, Peng Lv, Peng Fu, Xiaobing Jiang(a, d) Kaplan–Meier curves for OS in the CGGA693-GBM and CGGA325-GBM cohort stratified by 12 TMZR-RDEGs model in high- and low-risk. (b, e) The distribution plots of TMZR-RGPI, survival status and expression of 12 selected TMZR-RDEGs in the CGGA693-GBM and CGGA325-GBM cohort. (c, f) Time dependent ROC curves for TMZR-RGPI model in the CGGA693-GBM and CGGA325-GBM cohort.
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xlink "> glioblastomavaluable prognostic toolpoorer patient prognosislethal primary tumorindependent predictive factoridentify biomarkers associateddemonstrated high efficacycomprehensive prognostic modelcombining differential expressioncentral nervous systemassessed cell proliferationrisk score modelglioblastoma selected 12 tmzrnovel temozolomide resistancerisk score12 tmzrwound healingwhose rolewell understoodvitro experimentsvitro assaysunderlying mechanismstranswell assayssurvival analysisstudy providesstudy aimsstratified analysesmutation analysesmultifaceted approachincluding cckfunctional enrichmentenhanced sensitivitydependent roccritical target
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