pone.0208537.g006.tif (1.18 MB)
Treatment with a fixed dose combination antiretroviral therapy drug containing tenofovir, emtricitabine and efavirenz is associated with cardioprotection in high calorie diet-induced obese rats - Fig 6
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posted on 2018-12-05, 18:59 authored by Frans Everson, Amanda Genis, Temitope Ogundipe, Patrick De Boever, Nandu Goswami, Amanda Lochner, Dee Blackhurst, Hans StrijdomWestern blot measurements of AMPK protein expression and phosphorylation at (a) baseline conditions, and (b) post-global I/R conditions.n = 3–4 /group. ap < 0.05 vs. Control, bp < 0.05 vs. Control+ART. Data analysed by 1-way ANOVA (followed by Tukey’s multiple comparison).
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rats HIV-infectionFDC ART-induced cardioprotectionprotease inhibitorsinfract size6- weeks treatmentdose combination antiretroviral therapy drugIHDischaemic heart diseasePI-free FDC ARTdose combinationantiretroviral drug classesFDC ARTantiretroviral therapyART-experienced individualsEFVFTCnitric oxide synthaseischaemia-reperfusion injuryFDC ART drugWorld Health Organisation guidelinesfirst-line HIV treatmentObese ratsAMP-kinase levelstranscriptase inhibitorscalorie dietTDFART initiation16 weeksHIV-infected populations16- weekcalorie diet-inducedFDC ART treatmentwistar ratsTBARS levelsobesity rates
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