Trans eQTL associations in a region of chromosome 12.

The purple “+” symbols in the figure represent single SNP-trait associations in the Gonzales et al. [4] analysis that had p-value less than 9.01 × 10⁻⁶. Among the purple crosses, a single SNP may appear multiple times with different p-values in the figure, representing tests of the same SNP with different traits. The −log₁₀ of these p-values are displayed on the right-hand axis. The left-hand axis represents a Bonferroni-corrected version of the right-hand axis, in which a correction for testing 14,078 traits is made. The ADELLE global testing result for each SNP in the region is shown as an orange dot whose p-value on the −log₁₀ scale is shown on the left-hand axis, because the ADELLE p-value already accounts for testing multiple traits. The dotted line represents the genomewide significance threshold, correcting for both multiple SNPs and multiple traits. Note that this dotted line is more stringent than the one used in Gonzales et al. because we have applied a Bonferroni correction for the number of traits (i.e. gene expressions) tested at each SNP.