The second biosynthesis pathway of taxadiene in S. cerevisiae retrieved by PyMiner.

Instead of the endogenous HMGR, exogenous enzyme mvaA catalyzes the synthesis of (R)-Mevalonate with the participation of NADH. The green arrows indicate endogenous steps while the blue arrows denote exogenous steps. The green circles highlight the atom transfer route from acetyl-CoA to taxadiene. The abbreviations are: ERG10, acetyl-CoA acetyltransferase; HMGS, HMG-CoA synthase; mvaA, hydroxymethylglutaryl-CoA reductase; ERG12, mevalonate kinase; ERG8, phosphomevalonate kinase; ERG19, mevalonate diphosphate decarboxylase; ERG20, farnesyl diphosphate synthase; and BTS1, geranylgeranyl diphosphate synthase.

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