The effect of SARS-CoV-2 infection on Tryptophan hydroxylase 2 (TPH2) expression in the k18hACE2 mice ventral tegmental area.

(A) Immunohistochemistry staining analysis of TPH2 in the Vt area of the brain section from k18hACE2 mice uninfected or infected with 5 × 10⁴ PFU 7 days after administration. Bar is 200 μm. (B) Western blot analysis of TPH2 expression in tissue lysate of the VTA in the brain of k18hACE2 mice uninfected or infected with 5 × 10⁴ PFU 7 days after administration. The intensity of the bands corresponding to TPH2 was normalized to that of β-actin. The data are representative of 6 mice per group, **P < 0.01.