Synthetic MCTR dose dependently accelerate tissue regeneration in planaria.

(A-C) Planaria were surgically injured, then kept in water containing (A) MCTR1 (1 or 100nM) (B) MCTR2 (1 or 100nM) (C) MCTR3 (1 or 100nM) or vehicle (water containing 0.01% EtOH), and tissue regeneration was assessed (see Materials and Methods for details). TRI₅₀, time to 50% regeneration. (D) Rank order potency at promoting tissue regeneration measured at Day 2 post-surgery for 100nM MCTR. Results are mean ± SEM. n = 8 planaria per group. *p<0.05, **p<0.01, #p<0.001, ##p<0.0001 vs. surgical Injury + vehicle; §p<0.05 vs. surgical Injury + MCTR1.