pone.0203567.g017.tif (78.73 kB)

Synthesis of tertiary alcohol 5.

Download (78.73 kB)
posted on 07.09.2018, 17:57 by Dawn M. George, Raymond J. Huntley, Kevin Cusack, David B. Duignan, Michael Hoemann, Jacqueline Loud, Regina Mario, Terry Melim, Kelly Mullen, Gagandeep Somal, Lu Wang, Jeremy J. Edmunds

Reagents and conditions: (a) but-3-en-2-one, Cs2CO3, DMF, rt, 73%; (b) MeMgBr, THF, rt, 38% (+ 44% recovered 33); (c) Pd(OH)2, H2 (1 atm), MeOH/EtOAc/AcOH, rt, 62%.