pone.0203567.g017.tif (78.73 kB)
Synthesis of tertiary alcohol 5.
figure
posted on 2018-09-07, 17:57 authored by Dawn M. George, Raymond J. Huntley, Kevin Cusack, David B. Duignan, Michael Hoemann, Jacqueline Loud, Regina Mario, Terry Melim, Kelly Mullen, Gagandeep Somal, Lu Wang, Jeremy J. EdmundsReagents and conditions: (a) but-3-en-2-one, Cs2CO3, DMF, rt, 73%; (b) MeMgBr, THF, rt, 38% (+ 44% recovered 33); (c) Pd(OH)2, H2 (1 atm), MeOH/EtOAc/AcOH, rt, 62%.
