Survival-related alternative splicing events in LUAD patients in the TCGA database.

(A) UpSet plot of alternative splicing events and the corresponding genes. (B) PSI values (left panel) and counts (right panel) of tumor and control tissues. (C) ROC curves of risk scores for 1-, 3-, and 5-year survival in LUAD patients in the TCGA database. Left panel, all patients. Right panel, metastatic patients. (D) Kaplan–Meier overall survival curves of all patients (left panel) and metastatic patients (right panel) grouped by risk score. (E) Risk score of each TNM classification and tumor stage. (F) ROC curves of risk scores for 1-, 3-, and 5-year survival in LUAD patients in the TCGA database for each alternative splicing event type. AA, alternative acceptor site; AD, alternative donor site; AP, alternative promoter; AT, alternative terminator; ES, exon skipping; RI, retained intron; ME, mutually exclusive exon.