pone.0216085.g007.tif (186.29 kB)
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posted on 2019-05-08, 17:35 authored by Gabriele Sass, Shajia R. Ansari, Anna-Maria Dietl, Eric Déziel, Hubertus Haas, David A. StevensIn need for iron P. aeruginosa (Pa) produces its siderophore pyoverdine (PYOV). PYOV-chelated iron is not available to A. fumigatus (Af), resulting in iron deficiency and damage to the fungus. Anti-fungal activity in part is counter-balanced by SidA-dependent A. fumigatus hydroxamate siderophores, providing iron to the fungus, further denying iron from P. aeruginosa.
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fumigatus biofilmsaeruginosa supernatantsfumigatus siderophoresiron chelator deferiproneAspergillus fumigatus siderophoresPseudomonas aeruginosa Pseudomonas aeruginosaco-inhabiting immunocompromised patient airwaysAf Δ sidA biofilmDFPfumigatus siderophore production inhibitor celastrolfumigatus planktonic supernatantsaeruginosa siderophore pyoverdinefumigatus hydroxamate siderophoresfumigatus biofilm
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