pone.0296894.g001.tif (755.07 kB)
Study work flow of the UVMR and MVMR analyses revealed the causal associations between liver enzymes and diabetic microvascular complications.
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posted on 2024-01-17, 18:31 authored by Yang Li, Qiu ZhangStudy work flow of the UVMR and MVMR analyses revealed the causal associations between liver enzymes and diabetic microvascular complications.
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wide association studysup >&# 8722single nucleotide polymorphismspotential biological mechanismspleiotropy residual summultivariable mendelian randomization5 × 10serum aspartate aminotransferaseserum alanine aminotransferasewide significance (<independent causal effectdiabetic microvascular complicationsalp ), gamma206 – 1115 – 1univariable mendelian randomizationthree mvmr approachesprevious observational investigationsfive uvmr approachesdiabetes risk factorsindependent causal effectsggt ),diabetic retinopathyclinical significancecausal effectscausal associationsserum altuvmr revealeduk biobanksignificant associationssensitivity analysesminimization methodsliver enzymeslevel statisticslevel increasedglutamyl transferasegenetic instrumentsfinngen consortiumextended versionsearly preventionalkaline phosphatase017 ).006 ).
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