Structure and sequence of domain V of CVB3 IRES.
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posted on 2022-10-03, 17:34 authored by Jawhar Gharbi, Mohammed A. Almalki, Manel Ben M’hadhebPosition of introduced mutations (1–6) on IRES domain V producing CVB3 mutants (M1 to M6) are indicated.
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principal causative agentprimary molecular determinantfindings strongly suggestdiv >< p5 ’ utrvirus replicative capacitiyires element situatedires rna leadstranslation initiation efficiencycvb3 wild typewild typetranslation initiationtranslation efficiencyires rnareduced replicativecvb3 rnatranslation efficienciestranslation defectvivo vitro viral myocarditisviral genomevaccine availableresults demonstratepresent studynecrosis .<mutant virusesmutant particlesdomain vdifferent positionsdifferent levelsdecreased replicationcoxsackievirus b3clinical use
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