Sphe is involved in activation of immune response after a challenge with <i>E</i>. <i>faecalis</i>.

<p><i>drosomycin</i> expression 24 hours PI, normalized to <i>rp49</i> after immune challenge with <i>E</i>. <i>faecalis</i> (<i>ctrl</i> (<i>sphe</i>^{<b><i>Δ</i></b><i>11</i>} wild type flies) vs. <i>sphe</i>^{<b><i>Δ</i></b><i>49</i>} p<0.0261, <i>ctrl</i> vs. <i>sphe</i>^{<b><i>Δ</i></b><i>104</i>} p<0.02) (A) or after natural infection with <i>B</i>. <i>bassiana</i> 48 hours PI (C) or immune challenge with <i>M</i>. <i>luteus</i> (E). Survival rate after immune challenge with <i>E</i>. <i>faecalis</i> (<i>ctrl</i> vs. <i>sphe</i>^{<b><i>Δ</i></b><i>49</i>} p<0.032, <i>ctrl</i> vs. <i>sphe</i>^{<b><i>Δ</i></b><i>104</i>} p<0.0065) (B) or natural infection with <i>B</i>. <i>bassiana</i> (D).</p>