Single carbon metabolite levels differ between C57BL/6Mthfr-/- and C57BL/6 mice.

(A) Single Carbon metabolism pathway. C57BL/6Mthfr-/- mice demonstrate altered levels of single carbon metabolites (homocysteine, HCYS; cystathionine, CYSTAT; dimethylglycine, DMG; methylglycine, MG; methionine, METH; cysteine, CYS; glycine, GLY; alpha aminobutyrate, ABUT; serine, SER) in (B) serum and (C) whole lung tissue compared to C57BL/6 mice (C57BL/6 black bars; C57Bl/6Mthfr-/- white bars, * p-value <0.05, *** p-value <0.001).