Simulation of degraded cartilage area.

Temporal estimations of degraded cartilage area with A) biochemical and combined biochemical and biomechanical degradation and B) biomechanical degradation. In these simulations, cartilage was considered”degraded” when FCD loss in elements was equal or greater than 20%. See S1 Supplementary Material (Subsection S2.4, S5 Fig, S1–S4 Animation) for animations showing the propagation of the degraded area over time.