pone.0232849.g002.tif (8.64 MB)
Sequence conservation/variation and evolutionary importance of HLA I peptide-binding groove positions.
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posted on 2020-05-18, 17:32 authored by Onur Serçinoğlu, Pemra Ozbek(A) Sequence logo of the HLA I peptide-binding groove (residues 1–180). Polar, neutral, basic, acidic and hydrophobic amino acids are colored green, purple, blue, red, and black, respectively. (B) real-value Evolutionary Trace (rvET) scores of binding groove positions. Low rvET scores indicate high evolutionary importance, and vice versa.
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protein interactionsfrustration perspective ClassHLA binding groovepMHC homology modelsKiller-cell Immunglobulin-like ReceptorsTCRfrustration analysisPLCbinding modeKIR-HLA interactionT-cell ReceptorsMajor Histocompatibility Complexpolymorphic proteinallelic diversityNatural Killer10000 allelesNKantigenic peptidesHLA helicesfrustration profilesfrustration patchescytotoxic T-cellsHLA peptide-binding groovePeptide Loading ComplexHuman Leukocyte AntigenSequence-structure-function relationships1436 HLAinteraction sitespeptide sequence space
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