Sequence conservation/variation and evolutionary importance of HLA I α-3 domain positions.
(A) Sequence logo of the HLA I α-3 domain (residues 181–261). Polar, neutral, basic, acidic and hydrophobic amino acids are colored green, purple, blue, red, and black, respectively. (B) real-value Evolutionary Trace (rvET) scores of α-3 domain positions. Low rvET scores indicate high evolutionary importance, and vice versa.