Sensitivity analysis of the odds ratios of SARS-CoV-2 positivity (PCR or ELISA) according to the past six months’ prescription drug use for only participants with submitted questionnaire answers prior to a positive SARS-CoV-2 test.

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posted on 2024-11-27, 18:40 authored by Aleksander Eiken, Sofie Bliddal, Marie Villumsen, Kasper K. Iversen, Henning Bundgaard, Rasmus B. Hasselbach, Jonas H. Kristensen, Pernille B. Nielsen, Mia M. Pries-Heje, Andreas D. Knudsen, Kamille Fogh, Jakob B. Norsk, Ove Andersen, Thea K. Fischer, Ram B. Dessau, Sisse R. Ostrowski, Christian Torp-Pedersen, Sisse B. Ditlev, Mikkel Gybel-Brask, Erik Sørensen, Lene H. Harritshøj, Fredrik Folke, Thomas Benfield, Frederik N. Engsig, Henrik E. Poulsen, Henrik Ullum, Ulla Feldt-Rasmussen, Susanne D. Nielsen, Jørgen Rungby

Adjusted odds ratios of having a positive SARS-CoV-2 test according to use of prescription drugs (yes/no) in the six months before date of infection, compared to negative controls matched on sex, age and chronic disease. Only participants with a valid questionnaire answer prior to the date of infection were included. Prescription drug categories are based on the Anatomical Therapeutic Chemical Classification System as defined by the World Health Organization (codes are listed in parenthesis). The analysis was adjusted for body mass index (BMI) (<18.5, 18,5–25,25–30, >30 kg/m², missing) smoking (yes, no, former smoker, missing), alcohol intake (0, 0–7, 7–15, >15 units per week, missing), educational level (none or short, middle, long, missing), patient contact (none, partly, full time, missing), and place of living (Capital Region or Region Zealand). *) Indicates SARS-CoV-2 positive fraction in percent of drug users and no-drug users, respectively. Abbreviations: Adj., adjusted. OR, odds ratio. PCR, polymerase chain reaction. SARS-Cov-2, Severe Acute Respiratory Syndrome Coronavirus-2.

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