Schematic diagram of the RAS signaling pathway.

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posted on 2024-10-22, 17:42 authored by Matthew D. Gregory, Kweku Ofosu-Asante, Jassy Mary S. Lazarte, Pablo E. Puente, Nada Tawfeeq, Nadine Belony, Yong Huang, Ite A. Offringa, Nazarius S. Lamango

Mediators whose cellular phosphorylation levels have so far been shown to be altered by PCAIs treatment are indicated by pink rectangles and previously developed drugs that target them by white rectangles. Created with BioRender. P indicates phosphorylation. RTK: Receptor tyrosine kinase.

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findings clearly show 5 &# 956 proteins rac 1 profound increases observed mapk proteins braf 91 %, respectively 76 %, respectively 120 %, respectively mapk signaling patterns mapk pathway enzymes ras signaling pathway mutated ras proteins suppress hyperactive g raf1 phosphorylation decreased inhibits cell migration common oncogenic mutations 7 irreversible inhibitor 48 h exposure 3 &# 956 27 suppressed full 17 pcais tested spheroid invasion observed tm mapk pathway cell migration related proteins protein signaling observed inhibition >- mutated situ western blotting targeted therapies specifically disrupt results support reagent revealed protein levels proapoptotic isoforms potential use phosphorylation levels phosphorylated due pcais treatments lung adenocarcinoma future work downstream mediators determination whether cells treated black americans black american 7 levels 3 μm 27 depleted

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Schematic diagram of the RAS signaling pathway.

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