SARS-CoV-2 spike mutations and accessibility scores.
Mutated residues in spike variants are marked by colored squares above the plot. Open squares indicate mutations at the furin cleavage site and D614G. The consensus epitope score of  is shown in orange, and the AAS considering glycans in blue. Grey shading in the plot indicates surface residues as listed in S1 Table. Variants are distinguished by color, as indicated in the legend. The N-terminal domain (NTD) and receptor-binding domain (RBD) are indicated at the bottom, as are the S1/S2 furin cleavage site (vertical dashed line) and the S2′ site (solid vertical line).