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SARS-CoV-2 infected Tryptophan hydroxylase 2 (TPH2)-positive cells in the ventral tegmental area.

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posted on 2024-10-30, 17:40 authored by Motoki Imai, Fumitaka Kawakami, Takayuki Uematsu, Toshihide Matsumoto, Rei Kawashima, Yoshifumi Kurosaki, Shun Tamaki, Shotaro Maehana, Takafumi Ichikawa, Hideaki Hanaki, Hidero Kitazato, Makoto Kubo
<p>Immunohistochemistry staining analysis of SARS-CoV-2 spike protein: red, TPH2: green, and DAPI: blue in the VTA of brain sections from k18hACE2 mice uninfected or infected with 5×10<sup>4</sup> PFU 7 days after administration. Bar is 50 μm.</p>

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    DOI - Is supplement to SARS-CoV-2 propagation to the TPH2-positive neurons in the ventral tegmental area induces cell death via GSK3β-dependent accumulation of phosphorylated tau

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    xlink "> covidx (&# 947ventral tegmental regionventral tegmental areausing brain tissueinfectious disease causedgsk3 &# 946decreased serotonin synthesisimmunohistochemical analysis revealedtryptophan hydroxylase 22 spike proteinphosphorylated tau protein18hace2 mice infectedphosphorylated tauinfected miceimmunohistochemical staining2 propagation2 infectionunderlying mechanismterm mentalsitu hybridizationresults suggestrecovering patientspositive neuronspositive cellsphysical distressmemory impairmentintranasal administrationincreased accumulationhistone h2acauses long

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