SARS-CoV-2 infected Tryptophan hydroxylase 2 (TPH2)-positive cells in the ventral tegmental area.
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posted on 2024-10-30, 17:40 authored by Motoki Imai, Fumitaka Kawakami, Takayuki Uematsu, Toshihide Matsumoto, Rei Kawashima, Yoshifumi Kurosaki, Shun Tamaki, Shotaro Maehana, Takafumi Ichikawa, Hideaki Hanaki, Hidero Kitazato, Makoto KuboImmunohistochemistry staining analysis of SARS-CoV-2 spike protein: red, TPH2: green, and DAPI: blue in the ventral tegmental area of brain sections from k18hACE2 mice uninfected or infected with 5×104 PFU 7 days after administration. Bar is 50 μm.
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xlink "> covidx (&# 947ventral tegmental regionventral tegmental areausing brain tissueinfectious disease causedgsk3 &# 946decreased serotonin synthesisimmunohistochemical analysis revealedtryptophan hydroxylase 22 spike proteinphosphorylated tau protein18hace2 mice infectedphosphorylated tauinfected miceimmunohistochemical staining2 propagation2 infectionunderlying mechanismterm mentalsitu hybridizationresults suggestrecovering patientspositive neuronspositive cellsphysical distressmemory impairmentintranasal administrationincreased accumulationhistone h2acauses long
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