SARS-CoV-2 infected K18-hACE2-Tg-mouse brain.
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posted on 2024-10-30, 17:40 authored by Motoki Imai, Fumitaka Kawakami, Takayuki Uematsu, Toshihide Matsumoto, Rei Kawashima, Yoshifumi Kurosaki, Shun Tamaki, Shotaro Maehana, Takafumi Ichikawa, Hideaki Hanaki, Hidero Kitazato, Makoto KuboImmunohistochemistry staining of (A) SARS-CoV-2 spike protein, (B) SARS-CoV-2 RNA in-situ hybridization of brain sections from k18hACE2 mice uninfected or infected with 5 × 104 PFU 7 days after administration. Bar is 200 μm. Western blot analysis of SARS-CoV-2 spike protein in the (C) frontal cortex, (D) olfactory blub, and (E) VTA from brain tissue lysates of k18hACE2 mice in uninfected or infected with 5×104 PFU 7 days after administration. The data are representative of 6 mice per group.
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