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SARS-CoV-2 infected K18-hACE2-Tg-mouse brain.

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posted on 2024-10-30, 17:40 authored by Motoki Imai, Fumitaka Kawakami, Takayuki Uematsu, Toshihide Matsumoto, Rei Kawashima, Yoshifumi Kurosaki, Shun Tamaki, Shotaro Maehana, Takafumi Ichikawa, Hideaki Hanaki, Hidero Kitazato, Makoto Kubo
<p>Immunohistochemistry staining of (A) SARS-CoV-2 spike protein, (B) SARS-CoV-2 RNA in-situ hybridization of brain sections from k18hACE2 mice uninfected or infected with 5 × 10<sup>4</sup> PFU 7 days after administration. Bar is 200 μm. Western blot analysis of SARS-CoV-2 spike protein in the (C) frontal cortex, (D) olfactory blub, and (E) VTA from brain tissue lysates of k18hACE2 mice in uninfected or infected with 5×10<sup>4</sup> PFU 7 days after administration. The data are representative of 6 mice per group.</p>

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    xlink "> covidx (&# 947ventral tegmental regionventral tegmental areausing brain tissueinfectious disease causedgsk3 &# 946decreased serotonin synthesisimmunohistochemical analysis revealedtryptophan hydroxylase 22 spike proteinphosphorylated tau protein18hace2 mice infectedphosphorylated tauinfected miceimmunohistochemical staining2 propagation2 infectionunderlying mechanismterm mentalsitu hybridizationresults suggestrecovering patientspositive neuronspositive cellsphysical distressmemory impairmentintranasal administrationincreased accumulationhistone h2acauses long

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