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Download fileRescue of Mcm5 mutant phenotype by the expression of Mcm5.
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posted on 23.06.2022, 20:05 authored by Irene Rubio-Ferrera, Pablo Baladrón-de-Juan, Luis Clarembaux-Badell, Marta Truchado-Garcia, Sheila Jordán-Álvarez, Stefan Thor, Jonathan Benito-Sipos, Ignacio Monedero CobetaFMRFa expression analysis in Mcm2-7 Complex gene related mutants. Immunostaining for proFMRFa and Eya in Control (A) and Mcm5, prospero>UAS-Mcm5 (B) at stage 18h AEL. Immunostaining for proFMRFa in Control, and mutants for the Mcm2-7 complex components Mcm2 (D), Mcm3 (E), Mcm4 (F), Mcm5 (G), Mcm6 (H), and Mcm7 (I) and the respective quantification of Tv4 FMRFa positive cells (J) Merge and individual antibody images are shown in each panel. Genotypes: (A, C) w1118. (B) prospero-Gal4/ UAS-Mcm5; Mcm5exc222, (D) Mcm2MI0634 (E) Mcm3smu (F) dpa1 (G) Mcm5exc222 (H) Mcm7 f03462.
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reduced progenitor proliferationhighly conserved heterodiv >< pcentral nervous systembmp retrograde signalingbmp receptor tkvhexameric protein complexdeveloping mouse cnshighly specific role7 complex phenocopiesdrosophila melanogaster </dna helicase mcm57 genes resultcns development outside7 complexmcm5 </drosophila </7 genesmcm complexgenes involveddna unwindingdna replicationselective roleresults suggestreplicative forkneuronal differentiationgrowth retardationfmrfa neuronestablished rolebegin addressingalso expressed>, indicating
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