Public Library of Science
pone.0196672.g001.tif (777.93 kB)

Random search spaces for false positive matches.

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posted on 2018-05-10, 17:31 authored by Lutz Fischer, Juri Rappsilber

To model matches where one correct and one incorrect partner are combined requires considering a linear random match space (A). In contrast, when modelling matches with two incorrect partners it requires construction of a quadratic random match space depending on whether the cross-linker is homodimeric, non-directional (B), homodimeric, directional (C), heterodimeric, non-directional (D), or heterodimeric, directional (E).