R54 counteracts proliferation and paclitaxel resistance CXCL12- mediated in CAOV3.
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posted on 2024-12-19, 18:37 authored by Daniela Russo, Anna Spina, Luigi Portella, Anna Maria Bello, Francesca Galdiero, Anna Maria Trotta, Caterina Ieranò, Giuseppina Rea, Sabrina Chiara Cecere, Elisabetta Coppola, Salvatore Di Maro, Sandro Pignata, Daniela Califano, Stefania Scala(A) Growth curves of CAOV3 in the presence of CXCL12 (100ng/ml), R54 (100nM), Cisplatin 5 μM and Paclitaxel 1 nM. Cells were counted after 24, 48 and 72 hours of culture. Data are presented as mean values ± Standard Deviation. * denote p < 0,05, ** denote p < 0,01, *** denote p < 0,001, **** denote p < 0,0001; (B) qRT-PCR for CXCR4 in CAOV3 were performed after treatment with Cisplatin 5 μM and Paclitaxel 1 nM. Gene expression was calculated using a 2-ΔΔCq method (normalized to the mean of GUSB and B2M) as the fold increase compared with untreated cells. Data are presented as mean values ± Standard Deviation. * denote p < 0,05.
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