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pntd.0008458.s005.ai (1.45 MB)

Protein sequence alignment of wild-type TbAQP2, TbAQP3, and the chimeric AQP2-3 detected in relapsing sleeping sickness patients from the Democratic Republic of Congo.

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posted on 2020-07-09, 17:54 authored by Juan F. Quintana, Juan Bueren-Calabuig, Fabio Zuccotto, Harry P. de Koning, David Horn, Mark C. Field

The sequence alignment was conducted using Jalview and MUSCLE for multiple sequence alignment. The NPA/NPS selectivity filter is indicated with red boxes, and predicted trans-membrane domain (TMDs) spans are also indicated.

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    PLOS Neglected Tropical Diseases

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    TbAQP 2 stabilityERcytoplasmic-oriented lysine residuesdrug resistanceubiquitin conjugation sitesTbAQP 2TbAQP 2 mediates pentamidine transl...flagellar pocket membraneTbAQP 2 mediates pentamidine sensit...

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