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Proposed metabolic pathways, compartmentalisation and metabolic remodelling in T. gondii and P. berghei.

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posted on 2014-07-17, 03:10 authored by Rebecca D. Oppenheim, Darren J. Creek, James I. Macrae, Katarzyna K. Modrzynska, Paco Pino, Julien Limenitakis, Valerie Polonais, Frank Seeber, Michael P. Barrett, Oliver Billker, Malcolm J. McConville, Dominique Soldati-Favre

(A) Schematic representation of the metabolism in T. gondii WT (left panel) and Tge1a_ko (right panel) incorporating data from this study. (B) Scheme of the metabolism in P. berghei WT (left panel) and Pbe1a_ko (right panel). For both (A) and (B), the remodelling of the parasites metabolism upon ablation of BCKDH activity is highlighted in green. Dotted lines represent drops and disruption in the corresponding reactions. Abbreviations: AcCoA, acetyl-CoA; α-KG, α-ketoglutarate; Cit, citrate; Glc, glucose; Glu, glutamate; Gln, glutamine; Lac, lactate; Mal, malate; OAA, oxaloacetic acid; PEP, phosphoenolpyruvate; Pyr, pyruvate; Suc, succinate. Enzymes in red: BCKDH, branched chain keto acid dehydrogenase; ACL, ATP-citrate lyase; ACS, Acetyl-CoA synthetase; CS-II, second isoform of citrate synthetase.