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Progression dynamics in response to SARS-CoV-2 infection without considering T cell exhaustion (ρ = 0).

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posted on 24.11.2021, 18:34 by Shun Wang, Mengqian Hao, Zishu Pan, Jinzhi Lei, Xiufen Zou

a. Time course of the ratio of infected cells (RIC) (out of 200 independent runs). The black dashed line is the threshold between the asymptomatic and symptomatic state. b. Comparison of incubation periods between simulations and real data in COVID-19. The black line shows the cumulative probability obtained from default values in Table A in S1 Text (out of 200 independent runs). The orange dots represent real data of incubation periods from Dataset 1. c. Two simulated trajectories were developed for the symptomatic and asymptomatic states (red and blue lines, respectively). (i)-(vi) respectively for the ratio of infected cells (RIC), extracellular virus concentration (Xex), intracellular virus concentration per cell (Xin), infected rate of susceptible cells, cytokine levels ([Cytokines]), and effector T cell counts ([Teffector]). Other parameters were assigned default values shown in Table A in S1 Text.