Fig 1.tif (5.29 MB)
Pressure-overload induced concentric hypertrophy and reactive fibrosis.
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posted on 2017-04-27, 19:20 authored by Vanessa Hertig, Kim Tardif, Marc Andre Meus, Natacha Duquette, Louis Villeneuve, Fanny Toussaint, Jonathan Ledoux, Angelino Calderone(Panel A) Left ventricular (LV) wall thickness, circumference, (Panel B) interstitial and perivascular fibrosis as determined by Masson Trichrome staining were significantly increased in suprarenal abdominal aorta constricted rats (SAC) versus sham rats. Analysis was performed on a subpopulation of SAC (n = 3) and sham (n = 4) rats and (*) denotes p<0.05 versus sham as determined by a student’s unpaired t-test.
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nestin expressionfibrotic rat heartcollagen typecalibre blood vesselsmuscle α- actin stainingpro-fibrotic peptide growth factorscollagen-expressing mesenchymal cellsnestin protein levelsfilament protein nestinTGF -β 1TGF -β 1 stimulationcollagen-immunoreactive mesenchymal cellsprolyl 4- hydroxylasepressure-overloaded heartphosphatidylinositol 3- kinaseNestin protein levelsreactive fibrotic responseIIcells co-expressing nestin
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