Potential RHIMS in VZV strains.
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(A) Amino acid sequence alignment of various VZV strains showing the ORF20 RHIM region and indicating the percentage of conservation and consensus sequence. Accession numbers of VZV sequences used: X04370.1, JF306641.2, JQ972913.1, DQ457052.1, KX262866.1, KU926322.1, DQ008355.1, DQ008354.1 The RHIM core is boxed (B) Amino acid sequence alignment of the RHIM identified in VZV ORF20 (Dumas) with potential RHIMs in the capsid triplex subunit 1 from other Varicelloviruses, Simian varicella virus (SVV), Cercopithecine herpesvirus 9 (CeHV-9), Bovine herpesvirus (BHV) -1 and -5, Bubaline herpesvirus 1 (BuHV-1), Equine herpesvirus (EHV) -, -4, -8 and -9, Pseudorabiesvirus (PRV), Feline herpesvirus -1 (FHV1), and Canine herpesvirus -1 (CaHV-1). (C) Immunoblot analysis of mock and VZV-infected HT-29s following with TNF (T; 30 ng/ml), BV-6 (S; 1 μM), z-VAD-fmk (V; 25 μM). * represents a non-specific band, arrows indicate protein size markers.