Plasma SIV viral loads before ART were similar across groups.
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posted on 2025-01-10, 20:20 authored by Omotayo Farinre, Tzoalli Anaya, Alexis C. King, Kedan Endrias, Anne H. Hébert, Alison L. Hill, Sherrie Jean, Jennifer S. Wood, Stephanie Ehnert, Shan Liang, Gregory M. Laird, Rosemarie D. Mason, Mario Roederer, Jeffrey T. Safrit, Maud Mavigner, Ann Chahroudi(A), SIV RNA copies in plasma were tracked longitudinally following infection with SIVmac251 and treatment with ART. Grey shading indicates the period of ART administration. (B), Peak viral loads were compared across groups by one-way ANOVA. Individual data points are plotted with horizontal line drawn at the median. (C), Time to viral suppression, defined as three consecutive undetectable timepoints, was compared across groups by one-way ANOVA. Individual data points are plotted with mean and SD shown. ns = not significant; p > 0.05.
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observed biphasic decayki67 expressing nkformed within daysdiffer across groupscompetent viral reservoirintact siv provirusestreated group comparedproductively infected cellsperinatally acquired hivdiv >< p15 superagonist nsiv env rhmabsviral envelopesiv rhmabsoral sivweek 48specific rhesussingle doseresults supportprevent recrudescencepeople livingmajor barrierlymph nodeslifelong needincreased frequencyhiv curefollowing initiationexperimental treatmentsclearance nearcd8 +,antiretroviral therapy
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