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Pictures of boxer kidney with chronic kidney disease (CKD).
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posted on 2023-01-24, 18:35 authored by Frode Lingaas, Katarina Tengvall, Johan Høgset Jansen, Lena Pelander, Maria H. Hurst, Theo Meuwissen, Åsa Karlsson, Jennifer R. S. Meadows, Elisabeth Sundström, Stein Istre Thoresen, Ellen Frøysadal Arnet, Ole Albert Guttersrud, Marcin Kierczak, Marjo K. Hytönen, Hannes Lohi, Åke Hedhammar, Kerstin Lindblad-Toh, Chao Wang(A) A non-decapsulated kidney from an 8-month-old female boxer dog with CKD revealing a coarse nodular irregular cortical surface; (B) sagittal section of the kidney revealing an irregularly pale and thinned cortex; (C) LM revealing cortical interstitial fibrosis with tubular atrophy and multifocal infiltration of mononuclear inflammatory cells, (D) glomerulocystic atrophy (HE x10) and (E) hyperplasia of medullary collecting duct epithelium consistent with so-called “atypical tubuli” or “adenomatoid change” (HE x20).
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wide association analysiskidney cell linesfollowing comparative analysisanova test showedtotal four variantsthree intronic variantshuman regulatory datahuman kidney developmentckd phenotypic variation21 ckd regionsdiv >< pchronic kidney disease117 canine cases2 risk allelescanine ckd206 variantsprotective allelescases carriedhuman populationckd regiontop markerssignificantly higherreln one variantmay enlightenmagi2 intergenic regiongalnt18 fgfr2 also commonaffects 10
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