pntd.0011654.g002.tif (1.61 MB)
Phylogenetic relationships of the partial sequence of L, M and S segments of SFTSV strains.
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posted on 2023-09-18, 17:32 authored by Yu-ting Ren, Hong-pan Tian, Jia-le Xu, Man-qing Liu, Kun Cai, Shu-liang Chen, Xue-bing Ni, Yi-rong Li, Wei Hou, Liang-jun ChenThe ML trees were constructed based on the partial sequence alignment of L (700bp, A), M (500bp, B), and S (770bp, C) segments. The SFTSV strains detected in this study are indicated by bold black spots. The ML trees were constructed and tested by bootstrap analysis with 1000 iterations and only bootstrap values above 70% are shown. Ten genotypes, colored in pink, purple, red, yellow, green, cyan, blue, fuchsia, gray and brown evolutionary branches were designated as genotype J1, J2, J3, J4, C1, C2, C3, C4, C5 and C6, respectively. (D) The number and proportion of different genotypes obtained from patients with SFTS in each studied year.
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virus genome variationlimited sample sizel genome sequenceshigher mortality comparedcase fatality rates88 virus strains8 recombination strainsleast 6 genotypesextensive genetic diversityhubei province basedthrombocytopenia syndrome virusphylogenetic analysis revealed2018 &# 8211viral genetic diversityhubei sftsv strainsclinical disease characteristics2022 hubei provincethrombocytopenia syndromedisease characteristicssftsv diversitygenetic exchangeviral mutationsfour genotypesclinical diseasessystematic researchsignificantly elevatedsftsv prevalentsftsv ),severe feverserum amyloidrelatively frequentprofound changesinflammatory biomarkerincidence areaemerging tickdynamic shiftdominant genotypedepth monitoringdata summarizeconducted timelyborne bunyavirus
