Fig 3.tif (1.24 MB)
Phenotype of Col2-DKO mice.
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posted on 2017-12-29, 18:34 authored by Miki Shimbo, Riku Suzuki, Sayaka Fuseya, Takashi Sato, Katsue Kiyohara, Kozue Hagiwara, Risa Okada, Hiromasa Wakui, Yuki Tsunakawa, Hideto Watanabe, Koji Kimata, Hisashi Narimatsu, Takashi Kudo, Satoru Takahashi(A) Representative photograph of Control pups and Col2-DKO littermates at E18.5, P7, and P14. Scale bar: 1 cm. (B) Body weight of Control (E18.5; n = 16, P7; n = 4, P14; n = 4) and Col2-DKO (E18.5; n = 12, P7; n = 4, P14; n = 4) mice at various stages. *P < 0.05, **P < 0.01. (C) Humeral and tibial bone length at E18.5 of Control (n = 6) and Col2-DKO (n = 7) mice. (D) Quantitative analysis of t1 and t2 transcripts in the knee cartilage of WT (n = 3) and Col2-DKO (n = 3) mice at E18.5 using real-time RT-PCR. The expression of each transcript was normalized to that of β-actin. **P < 0.01.
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WTQuantitative RT-PCR analysist 2t 1CS synthesiscartilage-specific t 1t 1 KO miceCol 2a 1chondrocyteendochondral ossificationECMCS contentPtch 1 transcriptst 2 KO micechondroitin sulfate NGAG expression levelst 1 KO cartilage-2 Chondroitin sulfateCol 2-DKO miceDKO cartilaget 1 KOE 18.5 cartilageCol 2-DKO knee cartilage
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