Peptide-drug conjugate structure and cell viability.
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posted on 2021-02-26, 12:53 authored by Masataka Michigami, Kentaro Takahashi, Haruna Yamashita, Zhengmao Ye, Ikuhiko Nakase, Ikuo Fujii(a) Structure of peptide-drug conjugate M49K-vcMMAE. (b) Cell viability assay. HUVECs were treated with VEGF (25 ng/mL) and peptide-drug conjugates. After 24 h, cell viability was measured using WST-1 reagent. The data represent the mean ± standard deviation (n = 3).
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confocal fluorescence microscopymonomethyl auristatin Epeptide M 49VEGF receptor-mediated endocytosisintracellular drug deliveryHLHbackbone-cyclized peptide M 49KVEGF-binding helix-loop-helix peptidesTargeted intracellular drug deliveryPDCreceptor-mediated endocytosisconjugateVEGF-induced HUVEC proliferation
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