Nude Mouse Xenograft Model Studies.
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posted on 2017-01-03, 19:07 authored by Qing Chen, Ziyi Weng, Yunshu Lu, Yijun Jia, Longlong Ding, Fang Bai, Meixin Ge, Qing Lin, Kejin WuZR-75-1 (a) and BT-474 (b) tumor xenografts excised from female BALB/c (nu/nu) nude mice after four-week treatments with trastuzumab and fulvestrant as single agents or in combination. Days versus tumor volume curves for ZR-75-1 (c) and BT-474 (d) tumor xenografts show that trastuzumab and fulvestrant as single agents or in combination significantly inhibited tumor growth (P<0.05) and that tumor growth in the combination group was notably much more inhibited compared with that in individually treated groups (P<0.05).
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BT -474 cell linetrastuzumabMouse Tumor Xenografts Purposevivo mouse xenograft modelscombinationZR -75-1 cell lineG 1 phaseHRvivo tumor xenograftsprotein expression levelsZR -75-1BT -474 cell linesCIBALBResults Cell proliferationagentp-Erk protein expression levelsmouse xenograft tissuefulvestranttumor growthprotein p-MED 1cell cycle progression
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