pgen.1007660.g006.tif (1.77 MB)
Notch signaling was induced in the Pea3 mutant lacrimal gland.
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posted on 2018-09-06, 17:30 authored by Ankur Garg, Abdul Hannan, Qian Wang, Tamica Collins, Siying Teng, Mukesh Bansal, Jian Zhong, Keli Xu, Xin Zhang(A-B) GSEA analysis and Volcano plot data revealed that Notch pathway genes were enriched in Pea3 mutants. (C) The Pea3 knockout resulted in loss of the Notch regulator Lfng, induction of ligand Jag1 and ectopic expression of the effector, Notch-ICD, in the lacrimal gland bud (dotted lines). Scale bar, 50μm.
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cell fate determinationFGF-induced Pea 3 transcription factors programlandscapehigh-throughput gene expressionchromatin immunoprecipitation datafeedback loopsPea 3 familyepidermal cell fatefamily genestranscription factorsductal elongationcell fate determination FGFlacrimal gland developmentPea 3 geneslacrimal glandlacrimal gland epitheliumresponse transcriptional factors
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