pone.0284964.s012.tif (4.01 MB)
Necrosis in anchoring villi and ZIKV RNA in the trophoblastic shell.
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posted on 2023-05-04, 17:49 authored by Michelle R. Koenig, Ann M. Mitzey, Terry K. Morgan, Xiankun Zeng, Heather A. Simmons, Andres Mejia, Fernanda Leyva Jaimes, Logan T. Keding, Chelsea M. Crooks, Andrea M. Weiler, Ellie K. Bohm, Matthew T. Aliota, Thomas C. Friedrich, Emma L. Mohr, Thaddeus G. GolosRepresentative photomicrographs of paraffin embedded sections of the trophoblastic shell with necrosis in the anchoring villi from 45/14-2. Area of necrosis is outlined by dashed line. A) Pink staining shows ZIKV RNA detected using ISH in the trophoblastic shell. B) H&E stained serial section. Scale bar represents 100 μm.
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surgically terminated sevenhigh epidemic potentialgestational day 3014 days latermacaca mulatta experimental models suggestslineage zika virusadverse pregnancy outcomesfollowing maternal inoculationzikv vertical transmissionfetal interface tissueszikv rna detectedvertical transmissionzikv rnastudy suggestssitu multiple tissuesfetal interfacezikv inoculationlineage zikvdose inoculationlineage zikvslineage viruseszikv straininfectious zikvxlink ">visual systemvertically transmittedsubstantial effectstudy demonstratessignificant pathologyrecent evidencelow doseinoculated eitherincluding malformationsforming unitsfetal membranesfetal braindak ).birth defectsamniotic fluid44 plaque
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