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Natural history of HCV, screening, and treatment among PWID a, a PWID enter the model uninfected with HCV and HIV and may follow different health state trajectories as shown in the flow diagram.
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posted on 2016-10-06, 17:37 authored by Daniëla K. van Santen, Anneke S. de Vos, Amy Matser, Sophie B. Willemse, Karen Lindenburg, Mirjam E. E. Kretzschmar, Maria Prins, G. Ardine de WitAt any point, PWID may acquire HIV or exit the model due to background mortality or HIV-related mortality among HIV-infected PWID. Dashed lines depict the health states where PWID can be screened for HCV. Arrowed lines depict annual transition probabilities with the exception of HCV-antibody screening (which takes place every two years).
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sensitivity analysesDAA-containing regimenstreatment strategiesScaling-up treatmentlife yeardirect-acting antiviralsConclusion HCV treatmentPWIDHCV treatment strategiesNetherlands Background PeopleICERindividual-based modelDAA therapycost-effectiveness ratiohepatitis C virusHCV transmission3 x treatment uptakeuptake ratesQALYpopulation benefitsHCV epidemicHIVHepatitis C TreatmentHCV treatmentscaling-up treatmentHCV incidencedisease progressiontreatment scale-up
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