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Download fileMutations in the spike protein of SARS-CoV-2 variants concentrate in regions of high epitope and accessibility scores.
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posted on 2023-01-24, 18:35 authored by Sören von Bülow, Mateusz Sikora, Florian E. C. Blanc, Roberto Covino, Gerhard HummerTop views (A, B) and side views (C, D) of spike. Pink spheres show positions of Omicron BA.1 mutations, red spheres show positions unique to Omicron BA.5 mutations, and yellow spheres are those in earlier variants. Intense purple surface shading in A and C indicates high consensus epitope score [18]. Intense cyan surface shading in B and D indicates high AAS. Structures are snapshots from earlier MD simulations [19]. Proteins were rendered with Visual Molecular Dynamics (VMD) v1.9.3 [20].
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host immune defensebased immune responsessteric shielding effectnewly emerging sarsexpected mutation activityantibody accessibility scoreaas correlate stronglyvariant spike proteinsomicron variant bahigh calculated escapabilityspike surface mutationssteric accessibilitymutation activityspike proteinsincluding omicronhigh valuesescape antibodyspike proteinxlink ">viral evolutiontime viewstrong predictorsteady emergenceprior infectionprimary targetpinpoint regionsearlier variantse .,available early1 infection
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