Molecular model of RpfC activation by DSF stimulation.
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posted on 2017-04-03, 17:52 authored by Zhen Cai, Zhi-Hui Yuan, Huan Zhang, Yue Pan, Yao Wu, Xiu-Qi Tian, Fang-Fang Wang, Li Wang, Wei QianLeft panel: when bacterial population size and extracellular DSF concentration are low, RpfC autokinase activity is inhibited by its juxtamembrane domain (OFF state). Right panel: when bacterial population and extracellular DSF concentration are high, DSF binds to the RpfC sensor and releases the inhibition of the juxtamembrane domain on autokinase activity, resulting in RpfC autophosphorylation (ON state).
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phytopathogenic bacterium Xanthomonas campestris pvallosterically activates histidine kinase RpfCDSF-RpfC interactionLeu 172FA activatesAla 178RpfC kinase activityallosteric mannerconstitutive activationfuture studiesbinding eventmembrane-bound receptors biochemicallycell-cell communicationDSF stimulationacid-length sensor regionCAvirulence regulationhistidine phosphotransferreceptor histidine kinaseallosteric changejuxtamembrane domainFatty acid DSFFA-HK recognitionbiofilm developmentactivates RpfC autokinase activitymedium-chain FA diffusible signal factor
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